Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.

Journal Article (Journal Article)

Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use.

Full Text

Duke Authors

Cited Authors

  • Popovich, IG; Zabezhinskii, MA; Anisimov, VN; Kovalenko, AL; Petrov, AY; Semenchenko, AV; Yashin, AI

Published Date

  • December 2003

Published In

Volume / Issue

  • 136 / 6

Start / End Page

  • 595 - 598

PubMed ID

  • 15500082

Electronic International Standard Serial Number (EISSN)

  • 1573-8221

International Standard Serial Number (ISSN)

  • 0007-4888

Digital Object Identifier (DOI)

  • 10.1023/b:bebm.0000020214.47787.12

Language

  • eng