Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.
Journal Article (Journal Article)
Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use.
Full Text
Duke Authors
Cited Authors
- Popovich, IG; Zabezhinskii, MA; Anisimov, VN; Kovalenko, AL; Petrov, AY; Semenchenko, AV; Yashin, AI
Published Date
- December 2003
Published In
Volume / Issue
- 136 / 6
Start / End Page
- 595 - 598
PubMed ID
- 15500082
Electronic International Standard Serial Number (EISSN)
- 1573-8221
International Standard Serial Number (ISSN)
- 0007-4888
Digital Object Identifier (DOI)
- 10.1023/b:bebm.0000020214.47787.12
Language
- eng