Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.
Journal Article (Journal Article)
The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.
Full Text
Duke Authors
Cited Authors
- Rose, G; Dato, S; Altomare, K; Bellizzi, D; Garasto, S; Greco, V; Passarino, G; Feraco, E; Mari, V; Barbi, C; BonaFe, M; Franceschi, C; Tan, Q; Boiko, S; Yashin, AI; De Benedictis, G
Published Date
- October 1, 2003
Published In
Volume / Issue
- 38 / 10
Start / End Page
- 1065 - 1070
PubMed ID
- 14580859
Electronic International Standard Serial Number (EISSN)
- 1873-6815
International Standard Serial Number (ISSN)
- 0531-5565
Digital Object Identifier (DOI)
- 10.1016/s0531-5565(03)00209-2
Language
- eng