A model of accelerated aging induced by 5-bromodeoxyuridine.
Journal Article (Journal Article)
We consider a scheme of aging with two possible mechanisms of senescence processes: aging with apoptosis and necrosis for differentiated cells and a multistage process of malignant transformation. Our model describes the multistage phenomena of aging and carcinogenesis by a set of stochastic equations using multivariate and diffusion processes. This model fits experimental data on the acceleration of aging processes from postnatal exposure to 5-bromodeoxyuridine (BrdU), and the induction of genome instability. The methods of stochastic modeling and computer simulation of the processes of aging and carcinogenesis have been used for the verification of the biological suggestions.
Full Text
Duke Authors
Cited Authors
- Butov, AA; Volkov, MA; Anisimov, VN; Sehl, ME; Yashin, AI
Published Date
- January 2002
Published In
Volume / Issue
- 3 / 3
Start / End Page
- 175 - 182
PubMed ID
- 12075136
Electronic International Standard Serial Number (EISSN)
- 1573-6768
International Standard Serial Number (ISSN)
- 1389-5729
Digital Object Identifier (DOI)
- 10.1023/a:1015647225196
Language
- eng