Mortality modeling: A review
Looking at survival in terms of biological indicators of aging has given rise to various models of mortality, some of which we review here. The most notable models are that of Strehler and Mildvan, which relates the force of mortality to the ability of organisms to compensate for stress, and that of Sacher and Trucco, which describes the role played by homeostatic forces in shaping the age-specific pattern of mortality. The analysis of longitudinal data in aging studies now incorporates the notions of heterogeneity and frailty, as well as that of changes in the "repair capacity" of organisms. Furthermore, attention is now being paid to evolutionary theory and to models of senescence. These models and directions for further research are discussed.
Yashin, AI; Iachine, IA; Begun, AS
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