Skip to main content
Journal cover image

The network and the remodeling theories of aging: historical background and new perspectives.

Publication ,  Journal Article
Franceschi, C; Valensin, S; Bonafè, M; Paolisso, G; Yashin, AI; Monti, D; De Benedictis, G
Published in: Experimental gerontology
September 2000

Two general theories, i.e. "the network theory of aging" (1989) and "the remodeling theory of aging" (1995), as well as their implications, new developments, and perspectives are reviewed and discussed. Particular attention has been paid to illustrate: (i) how the network theory of aging fits with recent data on aging and longevity in unicellular organisms (yeast), multicellular organisms (worms), and mammals (mice and humans); (ii) the evolutionary and experimental basis of the remodeling theory of aging (immunological, genetic, and metabolic data in healthy centenarians, and studies on the evolution of the immune response, stress and inflammation) and its recent development (the concepts of "immunological space" and "inflamm-aging"); (iii) the profound relationship between these two theories and the data which suggest that aging and longevity are related, in a complex way, to the capability to cope with a variety of stressors.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

September 2000

Volume

35

Issue

6-7

Start / End Page

879 / 896

Related Subject Headings

  • Saccharomyces cerevisiae
  • Mice
  • Inflammation
  • Immune System
  • Humans
  • Heat-Shock Proteins
  • Gerontology
  • Biological Evolution
  • Animals
  • Aging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D., & De Benedictis, G. (2000). The network and the remodeling theories of aging: historical background and new perspectives. Experimental Gerontology, 35(6–7), 879–896. https://doi.org/10.1016/s0531-5565(00)00172-8
Franceschi, C., S. Valensin, M. Bonafè, G. Paolisso, A. I. Yashin, D. Monti, and G. De Benedictis. “The network and the remodeling theories of aging: historical background and new perspectives.Experimental Gerontology 35, no. 6–7 (September 2000): 879–96. https://doi.org/10.1016/s0531-5565(00)00172-8.
Franceschi C, Valensin S, Bonafè M, Paolisso G, Yashin AI, Monti D, et al. The network and the remodeling theories of aging: historical background and new perspectives. Experimental gerontology. 2000 Sep;35(6–7):879–96.
Franceschi, C., et al. “The network and the remodeling theories of aging: historical background and new perspectives.Experimental Gerontology, vol. 35, no. 6–7, Sept. 2000, pp. 879–96. Epmc, doi:10.1016/s0531-5565(00)00172-8.
Franceschi C, Valensin S, Bonafè M, Paolisso G, Yashin AI, Monti D, De Benedictis G. The network and the remodeling theories of aging: historical background and new perspectives. Experimental gerontology. 2000 Sep;35(6–7):879–896.
Journal cover image

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

September 2000

Volume

35

Issue

6-7

Start / End Page

879 / 896

Related Subject Headings

  • Saccharomyces cerevisiae
  • Mice
  • Inflammation
  • Immune System
  • Humans
  • Heat-Shock Proteins
  • Gerontology
  • Biological Evolution
  • Animals
  • Aging