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Thyroid hormone action at the cellular, genomic and target gene levels.

Publication ,  Journal Article
Yen, PM; Ando, S; Feng, X; Liu, Y; Maruvada, P; Xia, X
Published in: Mol Cell Endocrinol
February 26, 2006

Thyroid hormone (TH) plays important roles in metabolism, growth and differentiation. Thyroid hormone receptors (TRs) are ligand-regulatable transcription factors that bind both TH and DNA enhancer sequences in the promoter region of target genes where they can interact with co-repressor and co-activator complexes. These interactons, in turn, have consequent effects on transcription. This review describes studies on TH action from our laboratory examining the cellular localization and motility of TRs using green fluorescent fusion proteins, gene expression profiles of TH in WT and TRalpha and TRbeta KO mice, as well as general transcription factor and co-activator recruitment on the promoters of target genes by TH in chromatin immunoprecipitation assays.

Duke Scholars

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

February 26, 2006

Volume

246

Issue

1-2

Start / End Page

121 / 127

Location

Ireland

Related Subject Headings

  • Transcription, Genetic
  • Thyroid Hormones
  • Receptors, Thyroid Hormone
  • Protein Isoforms
  • Promoter Regions, Genetic
  • Models, Molecular
  • Mice, Knockout
  • Mice
  • Humans
  • Hela Cells
 

Citation

APA
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ICMJE
MLA
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Yen, P. M., Ando, S., Feng, X., Liu, Y., Maruvada, P., & Xia, X. (2006). Thyroid hormone action at the cellular, genomic and target gene levels. Mol Cell Endocrinol, 246(1–2), 121–127. https://doi.org/10.1016/j.mce.2005.11.030
Yen, Paul M., Shinichiro Ando, Xu Feng, Ying Liu, Padma Maruvada, and Xianmin Xia. “Thyroid hormone action at the cellular, genomic and target gene levels.Mol Cell Endocrinol 246, no. 1–2 (February 26, 2006): 121–27. https://doi.org/10.1016/j.mce.2005.11.030.
Yen PM, Ando S, Feng X, Liu Y, Maruvada P, Xia X. Thyroid hormone action at the cellular, genomic and target gene levels. Mol Cell Endocrinol. 2006 Feb 26;246(1–2):121–7.
Yen, Paul M., et al. “Thyroid hormone action at the cellular, genomic and target gene levels.Mol Cell Endocrinol, vol. 246, no. 1–2, Feb. 2006, pp. 121–27. Pubmed, doi:10.1016/j.mce.2005.11.030.
Yen PM, Ando S, Feng X, Liu Y, Maruvada P, Xia X. Thyroid hormone action at the cellular, genomic and target gene levels. Mol Cell Endocrinol. 2006 Feb 26;246(1–2):121–127.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

February 26, 2006

Volume

246

Issue

1-2

Start / End Page

121 / 127

Location

Ireland

Related Subject Headings

  • Transcription, Genetic
  • Thyroid Hormones
  • Receptors, Thyroid Hormone
  • Protein Isoforms
  • Promoter Regions, Genetic
  • Models, Molecular
  • Mice, Knockout
  • Mice
  • Humans
  • Hela Cells