Molecular basis of resistance to thyroid hormone.

Journal Article (Journal Article;Review)

Resistance to thyroid hormone (RTH) is a syndrome in which patients have raised serum thyroid hormone (TH) levels and raised or inappropriately normal thyrotropin (TSH) levels. In general, patients exhibit TH resistance in the pituitary and peripheral tissues. Novel techniques and genetically engineered mouse model systems have increased our understanding of thyroid hormone receptor (TR) action, and shed new light on the underlying molecular mechanisms for RTH. In particular, we are learning how mutant TRs from RTH patients can block wild-type TR function, with consequent effects in various tissues and cells. This dominant-negative activity has important implications for other hormone-resistant conditions and in hormone-sensitive tumors. This article examines the molecular basis of RTH.

Full Text

Duke Authors

Cited Authors

  • Yen, PM

Published Date

  • September 2003

Published In

Volume / Issue

  • 14 / 7

Start / End Page

  • 327 - 333

PubMed ID

  • 12946875

International Standard Serial Number (ISSN)

  • 1043-2760

Digital Object Identifier (DOI)

  • 10.1016/s1043-2760(03)00114-0


  • eng

Conference Location

  • United States