Molecular basis of resistance to thyroid hormone.
Journal Article (Journal Article;Review)
Resistance to thyroid hormone (RTH) is a syndrome in which patients have raised serum thyroid hormone (TH) levels and raised or inappropriately normal thyrotropin (TSH) levels. In general, patients exhibit TH resistance in the pituitary and peripheral tissues. Novel techniques and genetically engineered mouse model systems have increased our understanding of thyroid hormone receptor (TR) action, and shed new light on the underlying molecular mechanisms for RTH. In particular, we are learning how mutant TRs from RTH patients can block wild-type TR function, with consequent effects in various tissues and cells. This dominant-negative activity has important implications for other hormone-resistant conditions and in hormone-sensitive tumors. This article examines the molecular basis of RTH.
Full Text
Duke Authors
Cited Authors
- Yen, PM
Published Date
- September 2003
Published In
Volume / Issue
- 14 / 7
Start / End Page
- 327 - 333
PubMed ID
- 12946875
International Standard Serial Number (ISSN)
- 1043-2760
Digital Object Identifier (DOI)
- 10.1016/s1043-2760(03)00114-0
Language
- eng
Conference Location
- United States