Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.

Journal Article (Journal Article)

Thyroid hormone is a major regulator of postnatal brain development, but the precise molecular mechanisms underlying its action in this organ remain poorly understood. We used microarray analysis to identify new target genes in brain. Thyroid hormone treatment of hypothyroid Pax8(-/-) knockout mice, which lack thyroid follicular cells, had a very limited global effect on brain transcripts. This analysis mainly identified cyclin D2 as a new thyroid hormone target gene in the cerebellum of hypothyroid mice. Thyroid hormone receptor (TRalpha and/or TRbeta) knockout mice studies provided further genetic evidence that cyclin D2 is likely to mediate the antiapoptotic effect exerted by thyroid hormone on the cerebellum external granular layer neuroblasts but that this transcriptional activation is not directly exerted by the thyroid hormone receptors.

Full Text

Duke Authors

Cited Authors

  • Poguet, A-L; Legrand, C; Feng, X; Yen, PM; Meltzer, P; Samarut, J; Flamant, F

Published Date

  • February 15, 2003

Published In

Volume / Issue

  • 254 / 2

Start / End Page

  • 188 - 199

PubMed ID

  • 12591240

International Standard Serial Number (ISSN)

  • 0012-1606

Digital Object Identifier (DOI)

  • 10.1016/s0012-1606(02)00039-8


  • eng

Conference Location

  • United States