Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.
Published
Journal Article
Thyroid hormone is a major regulator of postnatal brain development, but the precise molecular mechanisms underlying its action in this organ remain poorly understood. We used microarray analysis to identify new target genes in brain. Thyroid hormone treatment of hypothyroid Pax8(-/-) knockout mice, which lack thyroid follicular cells, had a very limited global effect on brain transcripts. This analysis mainly identified cyclin D2 as a new thyroid hormone target gene in the cerebellum of hypothyroid mice. Thyroid hormone receptor (TRalpha and/or TRbeta) knockout mice studies provided further genetic evidence that cyclin D2 is likely to mediate the antiapoptotic effect exerted by thyroid hormone on the cerebellum external granular layer neuroblasts but that this transcriptional activation is not directly exerted by the thyroid hormone receptors.
Full Text
Duke Authors
Cited Authors
- Poguet, A-L; Legrand, C; Feng, X; Yen, PM; Meltzer, P; Samarut, J; Flamant, F
Published Date
- February 15, 2003
Published In
Volume / Issue
- 254 / 2
Start / End Page
- 188 - 199
PubMed ID
- 12591240
Pubmed Central ID
- 12591240
International Standard Serial Number (ISSN)
- 0012-1606
Digital Object Identifier (DOI)
- 10.1016/s0012-1606(02)00039-8
Language
- eng
Conference Location
- United States