Physiological and molecular basis of thyroid hormone action.

Journal Article (Journal Article;Review)

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and physiological function of virtually all tissues. TH binds to receptors that are ligand-regulatable transcription factors belonging to the nuclear hormone receptor superfamily. Tremendous progress has been made recently in our understanding of the molecular mechanisms that underlie TH action. In this review, we present the major advances in our knowledge of the molecular mechanisms of TH action and their implications for TH action in specific tissues, resistance to thyroid hormone syndrome, and genetically engineered mouse models.

Full Text

Duke Authors

Cited Authors

  • Yen, PM

Published Date

  • July 2001

Published In

Volume / Issue

  • 81 / 3

Start / End Page

  • 1097 - 1142

PubMed ID

  • 11427693

International Standard Serial Number (ISSN)

  • 0031-9333

Digital Object Identifier (DOI)

  • 10.1152/physrev.2001.81.3.1097


  • eng

Conference Location

  • United States