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Mechanisms of action selection and timing in substantia nigra neurons.

Publication ,  Journal Article
Fan, D; Rossi, MA; Yin, HH
Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
April 2012

The timing of actions is critical for adaptive behavior. In this study we measured neural activity in the substantia nigra as mice learned to change their action duration to earn food rewards. We observed dramatic changes in single unit activity during learning: both dopaminergic and GABAergic neurons changed their activity in relation to behavior to reflect the learned instrumental contingency and the action duration. We found the emergence of "action-on" neurons that increased firing for the duration of the lever press and mirror-image "action-off" neurons that paused at the same time. This pattern is especially common among GABAergic neurons. The activity of many neurons also reflected confidence about the just completed action and the prospect of reward. Being correlated with the relative duration of the completed action, their activity could predict the likelihood of reward collection. Compared with the GABAergic neurons, the activity of dopaminergic neurons was more commonly modulated by the discriminative stimulus signaling the start of each trial, suggesting that their phasic activity reflected sensory salience rather than any reward prediction error found in previous work. In short, these results suggest that (1) nigral activity is highly plastic and modified by the learning of the instrumental contingency; (2) GABAergic output from the substantia nigra can simultaneously inhibit and disinhibit downstream structures, while the dopaminergic output also provide bidirectional modulation of the corticostriatal circuits; (3) dopaminergic and GABAergic neurons show similar task-related activity, although DA neurons are more responsive to the trial start signal.

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Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

April 2012

Volume

32

Issue

16

Start / End Page

5534 / 5548

Related Subject Headings

  • Time Perception
  • Time Factors
  • Substantia Nigra
  • Statistics, Nonparametric
  • Reward
  • Reaction Time
  • ROC Curve
  • Principal Component Analysis
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
 

Citation

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Chicago
ICMJE
MLA
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Fan, D., Rossi, M. A., & Yin, H. H. (2012). Mechanisms of action selection and timing in substantia nigra neurons. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 32(16), 5534–5548. https://doi.org/10.1523/jneurosci.5924-11.2012
Fan, David, Mark A. Rossi, and Henry H. Yin. “Mechanisms of action selection and timing in substantia nigra neurons.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 32, no. 16 (April 2012): 5534–48. https://doi.org/10.1523/jneurosci.5924-11.2012.
Fan D, Rossi MA, Yin HH. Mechanisms of action selection and timing in substantia nigra neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Apr;32(16):5534–48.
Fan, David, et al. “Mechanisms of action selection and timing in substantia nigra neurons.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 32, no. 16, Apr. 2012, pp. 5534–48. Epmc, doi:10.1523/jneurosci.5924-11.2012.
Fan D, Rossi MA, Yin HH. Mechanisms of action selection and timing in substantia nigra neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Apr;32(16):5534–5548.

Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

April 2012

Volume

32

Issue

16

Start / End Page

5534 / 5548

Related Subject Headings

  • Time Perception
  • Time Factors
  • Substantia Nigra
  • Statistics, Nonparametric
  • Reward
  • Reaction Time
  • ROC Curve
  • Principal Component Analysis
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL