Inositol phosphate synthesis and the nuclear processes they affect.

Journal Article (Journal Article;Review)

Recent studies have implicated inositol phosphates, a highly charged family of lipid-derived metabolites, in a slue of cellular processes. However, it is their involvement in nuclear events that has attracted much attention. Several IP molecules have been linked to gene regulatory factors, chromatin-remodeling complexes, mRNA export, and DNA repair machinery, yet in many instances direct mechanistic roles remain elusive. The purpose of this review is to cover the latest data gathered regarding only the nuclear roles of the various inositol phosphates while simultaneously providing a step-by-step tour of IP synthesis in eukaryotes.

Full Text

Duke Authors

Cited Authors

  • Monserrate, JP; York, JD

Published Date

  • June 2010

Published In

Volume / Issue

  • 22 / 3

Start / End Page

  • 365 - 373

PubMed ID

  • 20359876

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England