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Inositol polyphosphate kinases: regulators of nuclear function.

Publication ,  Journal Article
Seeds, AM; York, JD
Published in: Biochem Soc Symp
2007

Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosphates. Discoveries of inositide receptors and novel mechanisms of inositide action have provided important insights into how such messengers couple to nuclear machinery. In this chapter, we discuss the IPK family members and the nuclear processes that their inositide products regulate.

Duke Scholars

Published In

Biochem Soc Symp

DOI

ISSN

0067-8694

Publication Date

2007

Issue

74

Start / End Page

183 / 197

Location

England

Related Subject Headings

  • Signal Transduction
  • Phosphotransferases (Phosphate Group Acceptor)
  • Models, Biological
  • Inositol Phosphates
  • Humans
  • Cell Nucleus
  • Animals
  • 0601 Biochemistry and Cell Biology
 

Citation

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MLA
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Seeds, A. M., & York, J. D. (2007). Inositol polyphosphate kinases: regulators of nuclear function. Biochem Soc Symp, (74), 183–197. https://doi.org/10.1042/BSS0740183
Seeds, Andrew M., and John D. York. “Inositol polyphosphate kinases: regulators of nuclear function.Biochem Soc Symp, no. 74 (2007): 183–97. https://doi.org/10.1042/BSS0740183.
Seeds AM, York JD. Inositol polyphosphate kinases: regulators of nuclear function. Biochem Soc Symp. 2007;(74):183–97.
Seeds, Andrew M., and John D. York. “Inositol polyphosphate kinases: regulators of nuclear function.Biochem Soc Symp, no. 74, 2007, pp. 183–97. Pubmed, doi:10.1042/BSS0740183.
Seeds AM, York JD. Inositol polyphosphate kinases: regulators of nuclear function. Biochem Soc Symp. 2007;(74):183–197.

Published In

Biochem Soc Symp

DOI

ISSN

0067-8694

Publication Date

2007

Issue

74

Start / End Page

183 / 197

Location

England

Related Subject Headings

  • Signal Transduction
  • Phosphotransferases (Phosphate Group Acceptor)
  • Models, Biological
  • Inositol Phosphates
  • Humans
  • Cell Nucleus
  • Animals
  • 0601 Biochemistry and Cell Biology