Inositol polyphosphate kinases: regulators of nuclear function.


Journal Article (Review)

Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosphates. Discoveries of inositide receptors and novel mechanisms of inositide action have provided important insights into how such messengers couple to nuclear machinery. In this chapter, we discuss the IPK family members and the nuclear processes that their inositide products regulate.

Full Text

Duke Authors

Cited Authors

  • Seeds, AM; York, JD

Published Date

  • 2007

Published In

Start / End Page

  • 183 - 197

PubMed ID

  • 17233590

Pubmed Central ID

  • 17233590

International Standard Serial Number (ISSN)

  • 0067-8694

Digital Object Identifier (DOI)

  • 10.1042/BSS0740183


  • eng

Conference Location

  • England