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Regulation of nuclear processes by inositol polyphosphates.

Publication ,  Journal Article
York, JD
Published in: Biochim Biophys Acta
2006

Inositide signaling pathways represent a multifaceted ensemble of cellular switches capable of regulating a number of processes, for example, intracellular calcium release, membrane trafficking, chemotaxis, ion channel activity and several nuclear functions. Over 30 inositide messengers are found in eukaryotic cells that may be grouped into two classes: (1) inositol lipids, phosphatidylinositols or phosphoinositides (PIPs) and (2) water-soluble inositol polyphosphates (IPs). This review will focus on inositol polyphosphate kinases (IPK) and inositol pyrophosphate synthases (IPS) responsible for the cellular production of IP(4), IP(5) IP(6) and PP-IPs. Of interest, IPK and IPS proteins localize, in part, within the nucleus and their activities are necessary for proper regulation of gene expression, mRNA export, DNA repair and telomere maintenance. The breadth of nuclear processes regulated and the evolutionary conservation of the genes involved in their synthesis have sparked renewed interest in inositide messengers derived from sequential phosphorylation of inositol 1,4,5-trisphosphate.

Duke Scholars

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

2006

Volume

1761

Issue

5-6

Start / End Page

552 / 559

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Phosphotransferases (Alcohol Group Acceptor)
  • Phosphatidylinositol Phosphates
  • Nuclear Envelope
  • Inositol Phosphates
  • Humans
  • Feedback
  • Cell Physiological Phenomena
  • Cell Nucleus
  • Animals
 

Citation

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ICMJE
MLA
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York, J. D. (2006). Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta, 1761(5–6), 552–559. https://doi.org/10.1016/j.bbalip.2006.04.014
York, John D. “Regulation of nuclear processes by inositol polyphosphates.Biochim Biophys Acta 1761, no. 5–6 (2006): 552–59. https://doi.org/10.1016/j.bbalip.2006.04.014.
York JD. Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta. 2006;1761(5–6):552–9.
York, John D. “Regulation of nuclear processes by inositol polyphosphates.Biochim Biophys Acta, vol. 1761, no. 5–6, 2006, pp. 552–59. Pubmed, doi:10.1016/j.bbalip.2006.04.014.
York JD. Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta. 2006;1761(5–6):552–559.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

2006

Volume

1761

Issue

5-6

Start / End Page

552 / 559

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Phosphotransferases (Alcohol Group Acceptor)
  • Phosphatidylinositol Phosphates
  • Nuclear Envelope
  • Inositol Phosphates
  • Humans
  • Feedback
  • Cell Physiological Phenomena
  • Cell Nucleus
  • Animals