A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.


Journal Article

Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6, was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.

Full Text

Duke Authors

Cited Authors

  • Odom, AR; Stahlberg, A; Wente, SR; York, JD

Published Date

  • March 17, 2000

Published In

Volume / Issue

  • 287 / 5460

Start / End Page

  • 2026 - 2029

PubMed ID

  • 10720331

Pubmed Central ID

  • 10720331

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.287.5460.2026


  • eng

Conference Location

  • United States