A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.


Journal Article

In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export.

Full Text

Duke Authors

Cited Authors

  • York, JD; Odom, AR; Murphy, R; Ives, EB; Wente, SR

Published Date

  • July 2, 1999

Published In

Volume / Issue

  • 285 / 5424

Start / End Page

  • 96 - 100

PubMed ID

  • 10390371

Pubmed Central ID

  • 10390371

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.285.5424.96


  • eng

Conference Location

  • United States