Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.
Published
Journal Article
DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.
Full Text
Duke Authors
Cited Authors
- Poltoratsky, VP; Shi, X; York, JD; Lieber, MR; Carter, TH
Published Date
- November 15, 1995
Published In
Volume / Issue
- 155 / 10
Start / End Page
- 4529 - 4533
PubMed ID
- 7594449
Pubmed Central ID
- 7594449
International Standard Serial Number (ISSN)
- 0022-1767
Language
- eng
Conference Location
- United States