Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.

Journal Article (Journal Article)

DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.

Full Text

Duke Authors

Cited Authors

  • Poltoratsky, VP; Shi, X; York, JD; Lieber, MR; Carter, TH

Published Date

  • November 15, 1995

Published In

Volume / Issue

  • 155 / 10

Start / End Page

  • 4529 - 4533

PubMed ID

  • 7594449

International Standard Serial Number (ISSN)

  • 0022-1767


  • eng

Conference Location

  • United States