Noise-limited frequency signal transmission in gene circuits.

Journal Article (Journal Article)

To maintain normal physiology, cells must properly process diverse signals arising from changes in temperature, pH, nutrient concentrations, and other factors. Many physiological processes are controlled by temporal aspects of oscillating signals; that is, these signals can encode information in the frequency domain. By modeling simple gene circuits, we analyze the impact of cellular noise on the fidelity and speed of frequency-signal transmission. We find that transmission of frequency signals is "all-or-none", limited by a critical frequency (f(c)). Signals with frequencies f(c) are severely corrupted or completely lost in transmission. We argue that f(c) is an intrinsic property of a gene circuit and it varies with circuit parameters and additional feedback or feedforward regulation. Our results may have implications for understanding signal processing in natural biological networks and for engineering synthetic gene circuits.

Full Text

Duke Authors

Cited Authors

  • Tan, C; Reza, F; You, L

Published Date

  • December 2007

Published In

Volume / Issue

  • 93 / 11

Start / End Page

  • 3753 - 3761

PubMed ID

  • 17704155

Pubmed Central ID

  • PMC2084236

Electronic International Standard Serial Number (EISSN)

  • 1542-0086

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1529/biophysj.107.110403


  • eng