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Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination.

Publication ,  Journal Article
Gorse, GJ; O'connor, TZ; Young, SL; Habib, MP; Wittes, J; Neuzil, KM; Nichol, KL
Published in: Chest
October 2006

BACKGROUND: We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (LDI)-caused illness, non-LDI-caused respiratory illness, or no illness, and for association with influenza vaccination. METHODS: Patients received either IM trivalent inactivated influenza virus vaccine (TIV) plus intranasal trivalent, live attenuated, cold-adapted influenza virus vaccine (TC) or TIV plus intranasal placebo (TP). We performed spirometry, measured the chronic lung disease severity index (CLDSI) score to assess functional status and well-being, and tested for influenza virus infection. RESULTS: Worsening in FEV(1), percentage of predicted FEV(1), and CLDSI score (p < 0.001) was associated with acute respiratory illness in 585 illnesses including 94 LDI-caused illnesses. LDI-caused illness was more likely to be associated with worsening in FEV(1) and CLDSI score acutely than non-LDI-caused illness (p < 0.01). Logistic regression showed acute respiratory illness (odds ratio [OR], 1.78; 95% confidence limit [CL], 1.40 to 2.26) to be associated with worsening in CLDSI score, and receipt of TC (OR, 1.39; 95% CL, 1.10 to 1.74) and no illness (OR, 0.70; 95% CL, 0.53 to 0.91 for acute respiratory illness) to be associated with better CLDSI score at the end of the study. Hospitalization was more frequent in patients with acute respiratory illness (p < 0.0001). CONCLUSIONS: Acute respiratory illness was associated with increased health-care utilization and obstruction to airflow, and worse functional status and well-being. At the end of the study, receipt of TC was associated with improvement and acute respiratory illness was associated with worsening in functional status and well-being.

Duke Scholars

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

October 2006

Volume

130

Issue

4

Start / End Page

1109 / 1116

Location

United States

Related Subject Headings

  • Vital Capacity
  • Veterans
  • Seasons
  • Respiratory System
  • Quality of Life
  • Pulmonary Disease, Chronic Obstructive
  • Middle Aged
  • Male
  • Influenza, Human
  • Influenza Vaccines
 

Citation

APA
Chicago
ICMJE
MLA
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Gorse, G. J., O’connor, T. Z., Young, S. L., Habib, M. P., Wittes, J., Neuzil, K. M., & Nichol, K. L. (2006). Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest, 130(4), 1109–1116. https://doi.org/10.1378/chest.130.4.1109
Gorse, Geoffrey J., Theresa Z. O’connor, Stephen L. Young, Michael P. Habib, Janet Wittes, Kathleen M. Neuzil, and Kristin L. Nichol. “Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination.Chest 130, no. 4 (October 2006): 1109–16. https://doi.org/10.1378/chest.130.4.1109.
Gorse GJ, O’connor TZ, Young SL, Habib MP, Wittes J, Neuzil KM, et al. Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest. 2006 Oct;130(4):1109–16.
Gorse, Geoffrey J., et al. “Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination.Chest, vol. 130, no. 4, Oct. 2006, pp. 1109–16. Pubmed, doi:10.1378/chest.130.4.1109.
Gorse GJ, O’connor TZ, Young SL, Habib MP, Wittes J, Neuzil KM, Nichol KL. Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest. 2006 Oct;130(4):1109–1116.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

October 2006

Volume

130

Issue

4

Start / End Page

1109 / 1116

Location

United States

Related Subject Headings

  • Vital Capacity
  • Veterans
  • Seasons
  • Respiratory System
  • Quality of Life
  • Pulmonary Disease, Chronic Obstructive
  • Middle Aged
  • Male
  • Influenza, Human
  • Influenza Vaccines