Morphometric characteristics of cells in the alveolar region of mammalian lungs.

Published

Journal Article

Morphometric procedures have been used to study the characteristics of cells in the alveolar region of the lungs of rats, dogs, baboons, and humans. Compared with the other species, human lungs were found to contain greater numbers of macrophages and to have larger alveolar type II, endothelial, and interstitial cells. The thickness of the interstitium and the pulmonary capillary endothelium were also significantly greater in the human lungs. These differences in human lung anatomy may be due to increased exposure to airborne pollutants and to tobacco smoke. Despite the above differences and the fact that there are large variations in size and functional characteristics of the lungs of these mammals, an overall striking similarity in characteristics of individual lung cells was found. The distribution of cells in alveolar tissue was remarkably constant between species as was the average volume and surface area of most cell types. Computer-aided three-dimensional reconstruction techniques were used to determine the spatial relationship of organelles in individual alveolar type II cells from rats. A three-dimensional reconstruction of cells permits quantification of number, size, surface area, and volume of subcellular organelles and correlations of their three-dimensional spatial relationships.

Full Text

Duke Authors

Cited Authors

  • Crapo, JD; Young, SL; Fram, EK; Pinkerton, KE; Barry, BE; Crapo, RO

Published Date

  • August 1983

Published In

Volume / Issue

  • 128 / 2 Pt 2

Start / End Page

  • S42 - S46

PubMed ID

  • 6881707

Pubmed Central ID

  • 6881707

International Standard Serial Number (ISSN)

  • 0003-0805

Digital Object Identifier (DOI)

  • 10.1164/arrd.1983.128.2P2.S42

Language

  • eng

Conference Location

  • United States