Numerical simulations of transcorneal tranport of ethacrynic acid


Journal Article

Potential trabecular meshwork (TM) drugs can be delivered with a lower concentration on the cornea surface over a long period of time for reducing the induced corneal toxicity. To determine the concentration of drugs that can be achieved in the TM, we developed a mathematical model to simulate axisymmetric transport of ethacrynic acid (ECA) from the cornea surface to the TM in a human eye. The results showed that the concentration of ECA could reach the therapeutic level at the TM site while the concentration of ECA on the cornea surface was maintained at an optimal level (75 μM) below the toxicity threshold. These results can be used to guide the design of controlled drug release devices.

Duke Authors

Cited Authors

  • Lin, CW; Yuan, F

Published Date

  • December 1, 2005

Published In

  • Proceedings of the 2005 Summer Bioengineering Conference

Volume / Issue

  • 2005 /

Start / End Page

  • 289 - 290

Citation Source

  • Scopus