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Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

Publication ,  Journal Article
Yuan, F; Leunig, M; Huang, SK; Berk, DA; Papahadjopoulos, D; Jain, RK
Published in: Cancer research
July 1994

Microvascular permeability and interstitial penetration of sterically stabilized liposomes in both normal s.c. tissue and human colon adenocarcinoma LS174T xenograft were quantified by using the dorsal skin-fold chamber implanted in severe combined immunodeficient mice and intravital fluorescence microscopy. Significant extravascular accumulation was the dominant feature of liposome distribution in tumors, whereas only minimal intramural accumulation in postcapillary and collecting venules was observed in normal s.c. tissue. The extravasated liposomes in tumors distributed heterogeneously and formed perivascular clusters that did not move significantly and could be observed for up to 1 week. The effective permeability of tumor vessels to liposomes (2.0 +/- 1.6 x 10(-8) cm/s; n = 23) was six times smaller than that to bovine serum albumin (1.2 +/- 0.5 x 10(-7) cm/s; n = 6). These results provide new insights into the mechanisms of transendothelial pathways of liposomes and improvements in liposome-mediated drug delivery.

Duke Scholars

Published In

Cancer research

EISSN

1538-7445

ISSN

0008-5472

Publication Date

July 1994

Volume

54

Issue

13

Start / End Page

3352 / 3356

Related Subject Headings

  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, SCID
  • Mice
  • Liposomes
  • Humans
  • Extracellular Space
  • Diffusion Chambers, Culture
  • Colonic Neoplasms
 

Citation

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Yuan, F., Leunig, M., Huang, S. K., Berk, D. A., Papahadjopoulos, D., & Jain, R. K. (1994). Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Research, 54(13), 3352–3356.
Yuan, F., M. Leunig, S. K. Huang, D. A. Berk, D. Papahadjopoulos, and R. K. Jain. “Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.Cancer Research 54, no. 13 (July 1994): 3352–56.
Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer research. 1994 Jul;54(13):3352–6.
Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer research. 1994 Jul;54(13):3352–3356.

Published In

Cancer research

EISSN

1538-7445

ISSN

0008-5472

Publication Date

July 1994

Volume

54

Issue

13

Start / End Page

3352 / 3356

Related Subject Headings

  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, SCID
  • Mice
  • Liposomes
  • Humans
  • Extracellular Space
  • Diffusion Chambers, Culture
  • Colonic Neoplasms