Radioimmunotherapy with alpha-particle emitting radionuclides.


Journal Article (Review)

An important consideration in the development of effective strategies for radioimmunotherapy is the nature of the radiation emitted by the radionuclide. Radionuclides decaying by the emission of alpha-particles offer the possibility of matching the cell specific reactivity of monoclonal antibodies with radiation with a range of only a few cell diameters. Furthermore, alpha-particles have important biological advantages compared with external beam radiation and beta-particles including a higher biological effectiveness, which is nearly independent of oxygen concentration, dose rate and cell cycle position. In this review, the clinical settings most likely to benefit from alpha-particle radioimmunotherapy will be discussed. The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized.

Full Text

Duke Authors

Cited Authors

  • Zalutsky, MR; Pozzi, OR

Published Date

  • December 2004

Published In

Volume / Issue

  • 48 / 4

Start / End Page

  • 289 - 296

PubMed ID

  • 15640792

Pubmed Central ID

  • 15640792

International Standard Serial Number (ISSN)

  • 1824-4785


  • eng

Conference Location

  • Italy