Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.

Journal Article (Journal Article)

The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [(211)At]astatide in the UVW human glioma cell line transfected to express NIS. [(211)At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [(131)I]iodide uptake. These studies suggest [(211)At]astatide as a possible alternative radionuclide to [(131)I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [(211)At]astatide behavior at a cellular level.

Full Text

Duke Authors

Cited Authors

  • Carlin, S; Mairs, RJ; Welsh, P; Zalutsky, MR

Published Date

  • October 2002

Published In

Volume / Issue

  • 29 / 7

Start / End Page

  • 729 - 739

PubMed ID

  • 12381453

International Standard Serial Number (ISSN)

  • 0969-8051

Digital Object Identifier (DOI)

  • 10.1016/s0969-8051(02)00332-3


  • eng

Conference Location

  • United States