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Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.

Publication ,  Journal Article
Carlin, S; Mairs, RJ; Welsh, P; Zalutsky, MR
Published in: Nucl Med Biol
October 2002

The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [(211)At]astatide in the UVW human glioma cell line transfected to express NIS. [(211)At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [(131)I]iodide uptake. These studies suggest [(211)At]astatide as a possible alternative radionuclide to [(131)I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [(211)At]astatide behavior at a cellular level.

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Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

October 2002

Volume

29

Issue

7

Start / End Page

729 / 739

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Symporters
  • Sodium Compounds
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Reference Values
  • Radiopharmaceuticals
  • Perchlorates
  • Nuclear Medicine & Medical Imaging
 

Citation

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Carlin, S., Mairs, R. J., Welsh, P., & Zalutsky, M. R. (2002). Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. Nucl Med Biol, 29(7), 729–739. https://doi.org/10.1016/s0969-8051(02)00332-3
Carlin, Sean, Robert J. Mairs, Phil Welsh, and Michael R. Zalutsky. “Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.Nucl Med Biol 29, no. 7 (October 2002): 729–39. https://doi.org/10.1016/s0969-8051(02)00332-3.
Carlin S, Mairs RJ, Welsh P, Zalutsky MR. Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. Nucl Med Biol. 2002 Oct;29(7):729–39.
Carlin, Sean, et al. “Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.Nucl Med Biol, vol. 29, no. 7, Oct. 2002, pp. 729–39. Pubmed, doi:10.1016/s0969-8051(02)00332-3.
Carlin S, Mairs RJ, Welsh P, Zalutsky MR. Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. Nucl Med Biol. 2002 Oct;29(7):729–739.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

October 2002

Volume

29

Issue

7

Start / End Page

729 / 739

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Symporters
  • Sodium Compounds
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Reference Values
  • Radiopharmaceuticals
  • Perchlorates
  • Nuclear Medicine & Medical Imaging