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Radioiodinated antibody targeting of the HER-2/neu oncoprotein.

Publication ,  Journal Article
Xu, FJ; Yu, YH; Bae, DS; Zhao, XG; Slade, SK; Boyer, CM; Bast, RC; Zalutsky, MR
Published in: Nucl Med Biol
July 1997

The HER-2/neu oncogene encodes a 185 kDa phosphoglycoprotein that is overexpressed in breast, ovarian and other cancers. Seven monoclonal antibodies reactive with oncoprotein were labeled with 131I. In vitro experiments with SKOv3 9002-18 cells determined binding affinity, internalization and degradation. The biodistribution of these antibodies in comparison to 125I-labeled nonspecific antibody was measured in athymic mice with SKOv3 9002-18 ovarian carcinoma xenografts. Antibody 520C9 exhibited the highest and most specific retention in tumor, peaking at 17.4 +/- 5.6% ID/g at 24 h.

Duke Scholars

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

July 1997

Volume

24

Issue

5

Start / End Page

451 / 459

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Tissue Distribution
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Radioimmunotherapy
  • Nuclear Medicine & Medical Imaging
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Iodine Radioisotopes
 

Citation

APA
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ICMJE
MLA
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Xu, F. J., Yu, Y. H., Bae, D. S., Zhao, X. G., Slade, S. K., Boyer, C. M., … Zalutsky, M. R. (1997). Radioiodinated antibody targeting of the HER-2/neu oncoprotein. Nucl Med Biol, 24(5), 451–459. https://doi.org/10.1016/s0969-8051(97)00065-6
Xu, F. J., Y. H. Yu, D. S. Bae, X. G. Zhao, S. K. Slade, C. M. Boyer, R. C. Bast, and M. R. Zalutsky. “Radioiodinated antibody targeting of the HER-2/neu oncoprotein.Nucl Med Biol 24, no. 5 (July 1997): 451–59. https://doi.org/10.1016/s0969-8051(97)00065-6.
Xu FJ, Yu YH, Bae DS, Zhao XG, Slade SK, Boyer CM, et al. Radioiodinated antibody targeting of the HER-2/neu oncoprotein. Nucl Med Biol. 1997 Jul;24(5):451–9.
Xu, F. J., et al. “Radioiodinated antibody targeting of the HER-2/neu oncoprotein.Nucl Med Biol, vol. 24, no. 5, July 1997, pp. 451–59. Pubmed, doi:10.1016/s0969-8051(97)00065-6.
Xu FJ, Yu YH, Bae DS, Zhao XG, Slade SK, Boyer CM, Bast RC, Zalutsky MR. Radioiodinated antibody targeting of the HER-2/neu oncoprotein. Nucl Med Biol. 1997 Jul;24(5):451–459.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

July 1997

Volume

24

Issue

5

Start / End Page

451 / 459

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Tissue Distribution
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Radioimmunotherapy
  • Nuclear Medicine & Medical Imaging
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Iodine Radioisotopes