Radioiodinated antibody targeting of the HER-2/neu oncoprotein.
Journal Article
The HER-2/neu oncogene encodes a 185 kDa phosphoglycoprotein that is overexpressed in breast, ovarian and other cancers. Seven monoclonal antibodies reactive with oncoprotein were labeled with 131I. In vitro experiments with SKOv3 9002-18 cells determined binding affinity, internalization and degradation. The biodistribution of these antibodies in comparison to 125I-labeled nonspecific antibody was measured in athymic mice with SKOv3 9002-18 ovarian carcinoma xenografts. Antibody 520C9 exhibited the highest and most specific retention in tumor, peaking at 17.4 +/- 5.6% ID/g at 24 h.
Full Text
Duke Authors
Cited Authors
- Xu, FJ; Yu, YH; Bae, DS; Zhao, XG; Slade, SK; Boyer, CM; Bast, RC; Zalutsky, MR
Published Date
- July 1997
Published In
Volume / Issue
- 24 / 5
Start / End Page
- 451 - 459
PubMed ID
- 9290082
Pubmed Central ID
- 9290082
International Standard Serial Number (ISSN)
- 0969-8051
Digital Object Identifier (DOI)
- 10.1016/s0969-8051(97)00065-6
Language
- eng
Conference Location
- United States