Radioiodinated antibody targeting of the HER-2/neu oncoprotein.

Journal Article

The HER-2/neu oncogene encodes a 185 kDa phosphoglycoprotein that is overexpressed in breast, ovarian and other cancers. Seven monoclonal antibodies reactive with oncoprotein were labeled with 131I. In vitro experiments with SKOv3 9002-18 cells determined binding affinity, internalization and degradation. The biodistribution of these antibodies in comparison to 125I-labeled nonspecific antibody was measured in athymic mice with SKOv3 9002-18 ovarian carcinoma xenografts. Antibody 520C9 exhibited the highest and most specific retention in tumor, peaking at 17.4 +/- 5.6% ID/g at 24 h.

Full Text

Duke Authors

Cited Authors

  • Xu, FJ; Yu, YH; Bae, DS; Zhao, XG; Slade, SK; Boyer, CM; Bast, RC; Zalutsky, MR

Published Date

  • July 1997

Published In

Volume / Issue

  • 24 / 5

Start / End Page

  • 451 - 459

PubMed ID

  • 9290082

Pubmed Central ID

  • 9290082

International Standard Serial Number (ISSN)

  • 0969-8051

Digital Object Identifier (DOI)

  • 10.1016/s0969-8051(97)00065-6

Language

  • eng

Conference Location

  • United States