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Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.

Publication ,  Journal Article
Foulon, CF; Schoultz, BW; Zalutsky, MR
Published in: Nucl Med Biol
February 1997

Biotinyl-3-[211 At]astatoanilide ([211 At]AtBA) was prepared in more than 80% yield by destannylation. In vitro, [211 At]AtBA exhibited a high affinity for streptavidin, and was stable after incubation in human serum, cerebrospinal fluid and distilled water, whereas it was rapidly degraded in mouse serum. HPLC analysis showed that the main degradation pathway in mouse serum was the cleavage of [211 At]astatoaniline. In mice, [211 At]AtBA and its 125I-labeled analogue cleared rapidly from most tissues; however, there was some evidence for dehalogenation of both tracers.

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Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

February 1997

Volume

24

Issue

2

Start / End Page

135 / 143

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Time Factors
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Kinetics
  • Iodine Radioisotopes
  • Humans
  • Drug Stability
  • Biotransformation
  • Biotin
 

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Foulon, C. F., Schoultz, B. W., & Zalutsky, M. R. (1997). Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. Nucl Med Biol, 24(2), 135–143. https://doi.org/10.1016/s0969-8051(96)00185-0
Foulon, C. F., B. W. Schoultz, and M. R. Zalutsky. “Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.Nucl Med Biol 24, no. 2 (February 1997): 135–43. https://doi.org/10.1016/s0969-8051(96)00185-0.
Foulon, C. F., et al. “Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.Nucl Med Biol, vol. 24, no. 2, Feb. 1997, pp. 135–43. Pubmed, doi:10.1016/s0969-8051(96)00185-0.
Foulon CF, Schoultz BW, Zalutsky MR. Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. Nucl Med Biol. 1997 Feb;24(2):135–143.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

February 1997

Volume

24

Issue

2

Start / End Page

135 / 143

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Time Factors
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Kinetics
  • Iodine Radioisotopes
  • Humans
  • Drug Stability
  • Biotransformation
  • Biotin