Para-[18F]fluorobenzylguanidine kinetics in a canine coronary artery occlusion model.

Journal Article (Journal Article)

BACKGROUND: The kinetics of para-[18F]fluorobenzylguanidine ([18F]PFBG) were investigated in a canine coronary artery occlusion model. METHODS AND RESULTS: Five dogs were imaged by positron emission tomography (PET) before and after complete surgical ligation of the left anterior descending coronary artery. PET studies included a 10-minute dynamic [13N]NH3 perfusion scan, followed 1 hour later by 3-hour dynamic [18F]PFBG scanning. [18F]PFBG and [13N]NH3 images demonstrated homogeneous myocardial uptake/perfusion before infarction. One hundred eighty minutes after [18F]PFBG administration, myocardial accumulation was decreased by 60% (day 2, 0.0065% +/- 0.0015% injected dose/ml) and 58% (day 16, 0.0069% +/- 0.003% injected dose/ml) compared with a similar myocardial region of interest from the preinfarction (0.016% +/- 0.005% injected dose/ml) study. Myocardial accumulation of [13N]NH3 at 9 minutes showed a 52% (day 2) and 7% (day 16) decrease compared with the preinfarction study. The accumulation of [18F]PFBG in the infarction was decreased significantly at 120 and 180 minutes on all postinfarction studies (p = 0.01). In three dogs a significant decrease in the myocardial norepinephrine concentration was documented in the area of infarction (237 +/- 94 ng/gm) versus the noninfarcted (1018 +/- 48 ng/gm) myocardium (p = 0.001). CONCLUSIONS: A decreased accumulation of [18F]PFBG was observed in the area of myocardial infarct in this canine model. The magnitude of the decrease in [18F]PFBG was larger than that seen with [13N]NH3 on day 16 after infarction, suggesting reperfusion and persistent sympathetic neuronal dysfunction.

Full Text

Duke Authors

Cited Authors

  • Berry, CR; Garg, PK; DeGrado, TR; Hellyer, P; Weber, W; Garg, S; Hansen, B; Zalutsky, MR; Coleman, RE

Published Date

  • 1996

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 119 - 129

PubMed ID

  • 8799237

International Standard Serial Number (ISSN)

  • 1071-3581

Digital Object Identifier (DOI)

  • 10.1016/s1071-3581(96)90004-5


  • eng

Conference Location

  • United States