N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate: synthesis and potential utility for the radioiodination of monoclonal antibodies.

Published

Journal Article

N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate (MATE) was synthesized in two steps from 4-methyl-3-iodobenzoic acid. Radioiododestannylation of MATE proceeded more slowly than N-succinimidyl 3-(tri-n-butylstannyl)benzoate (ATE), but for reaction periods of 10 min or more, identical yields were obtained. Paired-label biodistribution studies were performed in mice with an intact monoclonal antibody and an F(ab')2 fragment labeled using MATE, ATE and Iodogen. Thyroid uptake with MATE was low, comparable to that seen with ATE, and considerably lower than that observed when the Iodogen method was used. With the F(ab')2 fragment, kidney uptake using MATE was 8-fold higher than that observed when either the ATE or Iodogen methods were used.

Full Text

Duke Authors

Cited Authors

  • Garg, PK; Garg, S; Zalutsky, MR

Published Date

  • May 1993

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 379 - 387

PubMed ID

  • 8504279

Pubmed Central ID

  • 8504279

International Standard Serial Number (ISSN)

  • 0969-8051

Language

  • eng

Conference Location

  • United States