Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function in vivo.

Journal Article (Journal Article)

Ganglioside GM1 was labeled with 125I either directly or after conjugation to tyramine. Direct iodination of the sphingosine chain resulted in a compound which dehalogenated rapidly both in vitro and in vivo. The binding of the 125I[GM1-tyramine] conjugate to neuronal membranes in vitro was similar to that reported for 3H-GM1. The biodistribution of 125I activity after intravenous injection of 0.5 uM and 5 uM 125I[GM1-tyramine] in mice was also similar to that reported for 3H-GM1. This radioiodinated GM1 derivative might be useful for the study of ganglioside GM1 function in vivo.

Full Text

Duke Authors

Cited Authors

  • Zalutsky, M; Magistretti, P; Gallagher, P; Ghidoni, R

Published Date

  • October 1985

Published In

Volume / Issue

  • 17 / 10

Start / End Page

  • 897 - 912

PubMed ID

  • 4070340

International Standard Serial Number (ISSN)

  • 0031-6989

Digital Object Identifier (DOI)

  • 10.1016/0031-6989(85)90032-3


  • eng

Conference Location

  • United States