Research and clinical potential of receptor based radiopharmaceuticals.

Journal Article (Journal Article;Review)

Receptors are proteins that have specific binding affinity for substances that produce a physiological event in the body. Receptor-binding radiotracers are being used increasingly to study the function of receptors in health and disease. This review summarizes the proceedings of a symposium on research in the development of receptor-binding radiopharmaceuticals. The key phases in this research include: selection of the receptor system and ligand; synthesis of radiolabeled ligand; validation in animal models; and clinical application. Current research involves a variety of biological systems, such as butyrophenone neuroleptics for dopamine receptors and steroidal estrogens for the estrogen receptor. In the future, it is believed that receptor-binding radiopharmaceuticals will be useful, not only to validate receptor systems in vivo, but also to aid in the diagnosis and therapy of human diseases.

Full Text

Duke Authors

Cited Authors

  • Kilbourn, MR; Zalutsky, MR

Published Date

  • June 1, 1985

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 655 - 662

PubMed ID

  • 2987443

International Standard Serial Number (ISSN)

  • 0161-5505


  • eng

Conference Location

  • United States