Synthesis of 11 C-dl-tryptophan and its purification using high-pressure liquid chromatography


Journal Article

Carbon-11-dl-tryptophan has been produced from 11C-cyanide using a modified Bücherer-Strecker technique for synthesis and a high-pressure liquid chromatographic system for purification. More than 80 preparations have been run with an average radiochemical yield of 50% and synthesis and purification times of about 28 min. These modifications have significantly increased the level of 11C-tryptophan activity which is available for clinical use per mCi of 11C-cyanide. © 1981.

Full Text

Duke Authors

Cited Authors

  • Zalutsky, MR; Wu, J; Harper, PV; Wickland, T

Published Date

  • January 1, 1981

Published In

Volume / Issue

  • 32 / 3

Start / End Page

  • 182 - 184

International Standard Serial Number (ISSN)

  • 0020-708X

Digital Object Identifier (DOI)

  • 10.1016/0020-708X(81)90114-9

Citation Source

  • Scopus