Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function.

Published

Journal Article

Fetal grafts of normal cerebellar tissue were implanted into the cerebellum of Purkinje cell degeneration mutant mice (pcd/pcd), a model of adult-onset recessively inherited cerebello-olivary atrophy, in an attempt at correcting their cellular and motor impairment. Donor cerebellar cells engrafted in the appropriate sites, as evidenced by the pattern of expression of insulin-like growth factor-I (IGF-I) system genes. Bilateral cerebellar grafts led to an improvement of motor behaviors in balance rod tests and in the open field, providing evidence for functional integration into the atrophic mouse cerebellum and underscoring the potential of neural transplantation for counteracting the human cerebellar ataxias.

Full Text

Duke Authors

Cited Authors

  • Zhang, W; Lee, WH; Triarhou, LC

Published Date

  • January 1, 1996

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 65 - 71

PubMed ID

  • 8564845

Pubmed Central ID

  • 8564845

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm0196-65

Language

  • eng

Conference Location

  • United States