Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function.
Published
Journal Article
Fetal grafts of normal cerebellar tissue were implanted into the cerebellum of Purkinje cell degeneration mutant mice (pcd/pcd), a model of adult-onset recessively inherited cerebello-olivary atrophy, in an attempt at correcting their cellular and motor impairment. Donor cerebellar cells engrafted in the appropriate sites, as evidenced by the pattern of expression of insulin-like growth factor-I (IGF-I) system genes. Bilateral cerebellar grafts led to an improvement of motor behaviors in balance rod tests and in the open field, providing evidence for functional integration into the atrophic mouse cerebellum and underscoring the potential of neural transplantation for counteracting the human cerebellar ataxias.
Full Text
Duke Authors
Cited Authors
- Zhang, W; Lee, WH; Triarhou, LC
Published Date
- January 1996
Published In
Volume / Issue
- 2 / 1
Start / End Page
- 65 - 71
PubMed ID
- 8564845
Pubmed Central ID
- 8564845
International Standard Serial Number (ISSN)
- 1078-8956
Digital Object Identifier (DOI)
- 10.1038/nm0196-65
Language
- eng
Conference Location
- United States