Pulsating tandem microbubble for localized and directional single-cell membrane poration.
Journal Article (Journal Article)
The interaction of laser-generated tandem microbubble (maximum diameter of about 50 μm) with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation of alternating, directional microjets (with max microstreaming velocity of 10 m/s) and vortices (max vorticity of 350 000 s{-1}) in opposite directions. Localized and directional membrane poration (200 nm to 2 μm in pore size) can be produced by the tandem microbubble in an orientation and proximity-dependent manner, which is absent from a single oscillating microbubble of comparable size and at the same stand-off distance.
Full Text
Duke Authors
Cited Authors
- Sankin, GN; Yuan, F; Zhong, P
Published Date
- August 9, 2010
Published In
Volume / Issue
- 105 / 7
Start / End Page
- 078101 -
PubMed ID
- 20868077
Pubmed Central ID
- PMC3771526
Electronic International Standard Serial Number (EISSN)
- 1079-7114
International Standard Serial Number (ISSN)
- 0031-9007
Digital Object Identifier (DOI)
- 10.1103/physrevlett.105.078101
Language
- eng