Pulsating tandem microbubble for localized and directional single-cell membrane poration.

Journal Article (Journal Article)

The interaction of laser-generated tandem microbubble (maximum diameter of about 50  μm) with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation of alternating, directional microjets (with max microstreaming velocity of 10  m/s) and vortices (max vorticity of 350 000  s{-1}) in opposite directions. Localized and directional membrane poration (200 nm to 2  μm in pore size) can be produced by the tandem microbubble in an orientation and proximity-dependent manner, which is absent from a single oscillating microbubble of comparable size and at the same stand-off distance.

Full Text

Duke Authors

Cited Authors

  • Sankin, GN; Yuan, F; Zhong, P

Published Date

  • August 9, 2010

Published In

Volume / Issue

  • 105 / 7

Start / End Page

  • 078101 -

PubMed ID

  • 20868077

Pubmed Central ID

  • PMC3771526

Electronic International Standard Serial Number (EISSN)

  • 1079-7114

International Standard Serial Number (ISSN)

  • 0031-9007

Digital Object Identifier (DOI)

  • 10.1103/physrevlett.105.078101


  • eng