The role and regulation of mTOR in T-lymphocyte function.

Journal Article (Journal Article;Review)

The conversion of naïve T cells into effector T cells is initiated by stimulation through the T-cell receptor (TCR). Upon activation, T cells undergo significant morphological and functional changes, putting new metabolic demands on the cell. Past research has identified the mammalian target of rapamycin (mTOR) as a critical regulator of cell metabolism, and the development of new genetic models has begun to reveal an important role for this pathway in the homeostasis and function of T lymphocytes. In this review, we focus on the most recent findings that demonstrate the ability of mTOR to regulate T-cell activation, CD8(+) memory cell formation and function, and helper T lineage differentiation. Furthermore, we highlight the importance of tight control of mTOR signaling by tuberous sclerosis complex 1 for T-cell homeostasis, and the regulation of mTOR signaling by diacylglycerol kinases and the RasGRP1-Ras-Erk1/2 pathway in the context of TCR signaling.

Full Text

Duke Authors

Cited Authors

  • O'Brien, TF; Zhong, X-P

Published Date

  • June 2012

Published In

Volume / Issue

  • 60 / 3

Start / End Page

  • 173 - 181

PubMed ID

  • 22484804

Pubmed Central ID

  • PMC3376380

Electronic International Standard Serial Number (EISSN)

  • 1661-4917

Digital Object Identifier (DOI)

  • 10.1007/s00005-012-0171-4


  • eng

Conference Location

  • Switzerland