Receptor signaling in immune cell development and function.

Published

Journal Article

Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE transduces signal that promotes mast cell survival and induces mast cell activation. In dendritic cells and macrophages, the toll-like receptors recognize microbial pathogens and play critical roles for both innate and adaptive immunity against pathogens. Our research explores how signaling from these receptors is transduced and regulated to better understand these immune cells. Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages.

Full Text

Duke Authors

Cited Authors

  • Zhong, X-P; Shin, J; Gorentla, BK; O'Brien, T; Srivatsan, S; Xu, L; Chen, Y; Xie, D; Pan, H

Published Date

  • April 2011

Published In

Volume / Issue

  • 49 / 1-3

Start / End Page

  • 109 - 123

PubMed ID

  • 21128010

Pubmed Central ID

  • 21128010

Electronic International Standard Serial Number (EISSN)

  • 1559-0755

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1007/s12026-010-8175-9

Language

  • eng