Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.

Published

Journal Article

Much is known about how T cell receptor (TCR) engagement leads to T cell activation; however, the mechanisms terminating TCR signaling remain less clear. Diacylglycerol, generated after TCR ligation, is essential in T cells. Its function must be controlled tightly to maintain normal T cell homeostasis. Previous studies have shown that diacylglycerol kinase zeta (DGKzeta), which converts diacylglycerol to phosphatidic acid, can inhibit TCR signaling. Here we show that DGKzeta-deficient T cells are hyperresponsive to TCR stimulation both ex vivo and in vivo. Furthermore, DGKzeta-deficient mice mounted a more robust immune response to lymphocytic choriomeningitis virus infection than did wild-type mice. These results demonstrate the importance of DGKzeta as a physiological negative regulator of TCR signaling and T cell activation.

Full Text

Duke Authors

Cited Authors

  • Zhong, X-P; Hainey, EA; Olenchock, BA; Jordan, MS; Maltzman, JS; Nichols, KE; Shen, H; Koretzky, GA

Published Date

  • September 2003

Published In

Volume / Issue

  • 4 / 9

Start / End Page

  • 882 - 890

PubMed ID

  • 12883552

Pubmed Central ID

  • 12883552

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni958

Language

  • eng