Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240.

Journal Article (Journal Article)

The UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase LpxC catalyzes the committed reaction of lipid A biosynthesis, an essential pathway in Gram-negative bacteria. We report the backbone resonance assignments of the 34 kDa LpxC from Escherichia coli in complex with the antibiotic L-161,240 using multidimensional, multinuclear NMR experiments. The (1)H chemical shifts of complexed L-161,240 are also determined.

Full Text

Duke Authors

Cited Authors

  • Barb, AW; Jiang, L; Raetz, CRH; Zhou, P

Published Date

  • April 2010

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 37 - 40

PubMed ID

  • 19941092

Pubmed Central ID

  • PMC3631426

Electronic International Standard Serial Number (EISSN)

  • 1874-270X

Digital Object Identifier (DOI)

  • 10.1007/s12104-009-9201-5


  • eng

Conference Location

  • Netherlands