Skip to main content
Journal cover image

The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function.

Publication ,  Journal Article
Dimopoulos, M; Alegre, A; Stadtmauer, EA; Goldschmidt, H; Zonder, JA; de Castro, CM; Masliak, Z; Reece, D; Olesnyckyj, M; Yu, Z; Weber, DM
Published in: Cancer
August 15, 2010

BACKGROUND: In patients with multiple myeloma, renal impairment (RI) at the time of diagnosis is associated with poor survival. To the authors' knowledge, the current retrospective analysis presented is the first to assess the impact of various degrees of renal dysfunction on safety and efficacy outcomes in a large cohort of patients with relapsed and/or refractory multiple myeloma who received treatment with lenalidomide plus dexamethasone. METHODS: Three hundred fifty-three patients from 2 large phase 3 trials were randomized to receive lenalidomide (25 mg) plus dexamethasone (40 mg). For the purpose of this analysis, RI was defined according to the calculated creatinine clearance (CLCr) level as follows: mild or no RI (CLCr>or=60 mL/minute), moderate RI (CLCr from >or=30 mL/minute to <60 mL/minute), and severe RI (CLCr<30 mL/minute). RESULTS: The RI subgroups did not differ significantly in terms of the overall response rate (range, 50%-64%) or response quality (very good partial response or better, 27%-37%). In all RI subgroups, the time to progression and progression-free survival did not differ significantly compared with the mild or no RI group. Patients with RI experienced an increased incidence of thrombocytopenia, required more frequent lenalidomide dose reduction or interruption, and had shorter overall survival than patients with mild or no RI (P=.006). Lenalidomide plus dexamethasone led to improvement in renal function in the majority of patients. CONCLUSIONS: The results from this study indicated that, with careful monitoring of the CLCr level and adverse events as well as appropriate dose adjustments, lenalidomide plus dexamethasone is an effective and well tolerated treatment option for patients with multiple myeloma who have RI.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

August 15, 2010

Volume

116

Issue

16

Start / End Page

3807 / 3814

Location

United States

Related Subject Headings

  • Thalidomide
  • Renal Insufficiency
  • Recurrence
  • Oncology & Carcinogenesis
  • Multiple Myeloma
  • Middle Aged
  • Lenalidomide
  • In Vitro Techniques
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dimopoulos, M., Alegre, A., Stadtmauer, E. A., Goldschmidt, H., Zonder, J. A., de Castro, C. M., … Weber, D. M. (2010). The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function. Cancer, 116(16), 3807–3814. https://doi.org/10.1002/cncr.25139
Dimopoulos, Meletios, Adrian Alegre, Edward A. Stadtmauer, Hartmut Goldschmidt, Jeffrey A. Zonder, Carlos M. de Castro, Zvenyslava Masliak, et al. “The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function.Cancer 116, no. 16 (August 15, 2010): 3807–14. https://doi.org/10.1002/cncr.25139.
Dimopoulos M, Alegre A, Stadtmauer EA, Goldschmidt H, Zonder JA, de Castro CM, et al. The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function. Cancer. 2010 Aug 15;116(16):3807–14.
Dimopoulos, Meletios, et al. “The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function.Cancer, vol. 116, no. 16, Aug. 2010, pp. 3807–14. Pubmed, doi:10.1002/cncr.25139.
Dimopoulos M, Alegre A, Stadtmauer EA, Goldschmidt H, Zonder JA, de Castro CM, Masliak Z, Reece D, Olesnyckyj M, Yu Z, Weber DM. The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function. Cancer. 2010 Aug 15;116(16):3807–3814.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

August 15, 2010

Volume

116

Issue

16

Start / End Page

3807 / 3814

Location

United States

Related Subject Headings

  • Thalidomide
  • Renal Insufficiency
  • Recurrence
  • Oncology & Carcinogenesis
  • Multiple Myeloma
  • Middle Aged
  • Lenalidomide
  • In Vitro Techniques
  • Humans
  • Female