A 4-tiered classification of left ventricular hypertrophy based on left ventricular geometry: the Dallas heart study.

Journal Article (Journal Article)

BACKGROUND: Left ventricular hypertrophy (LVH) is traditionally classified as concentric or eccentric, based on the ratio of LV wall thickness to chamber dimension. We propose a 4-tiered LVH classification based on LV concentricity(0.67) (mass/end-diastolic volume(0.67)) and indexed LV end-diastolic volume (EDV). METHODS AND RESULTS: Cardiac MRI was performed in 2803 subjects and LVH (n=895) was defined by increased LV mass/height(2.7). Increased concentricity(0.67) and indexed EDV were defined at the 97.5th percentile of a healthy subpopulation. Four geometric patterns resulted: increased concentricity without increased EDV ("thick hypertrophy," n=361); increased EDV without increased concentricity ("dilated hypertrophy," n=53); increased concentricity with increased EDV ("both thick and dilated hypertrophy," n=13); and neither increased concentricity nor increased EDV ("indeterminate hypertrophy," n=468). Compared with subjects with isolated thick hypertrophy, those with both thick and dilated hypertrophy had a lower LV ejection fraction and higher NT-pro-BNP and BNP levels (P

Full Text

Duke Authors

Cited Authors

  • Khouri, MG; Peshock, RM; Ayers, CR; de Lemos, JA; Drazner, MH

Published Date

  • March 2010

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 164 - 171

PubMed ID

  • 20061518

Electronic International Standard Serial Number (EISSN)

  • 1942-0080

Digital Object Identifier (DOI)

  • 10.1161/CIRCIMAGING.109.883652


  • eng

Conference Location

  • United States