Assessment of age-related changes in left ventricular structure and function by freehand three-dimensional echocardiography.

Journal Article (Journal Article)

To determine age-related changes in left ventricular (LV) structure and function, the authors used freehand three-dimensional echocardiography, a previously validated tomographic technique, to measure LV mass, volumes, and derived parameters in 94 sedentary, but ambulatory and clinically healthy, adult male and female volunteers aged 20-94. LV volumes and mass were significantly greater in men than in women (p<0.001) and remained greater after adjustment for body surface area and height (p<0.05). Declines in end-diastolic and stroke volumes with age were reduced or absent after accounting for body size. By multivariate analysis, age accounted for only about 6%-11% of the variance among LV volumes and mass, in comparison with body surface area and gender, which accounted jointly for about 46%-77% of the variance. In conclusion, changes occur in LV structure and function with normal aging, but these changes are relatively minor when body size and gender are taken into account.

Full Text

Duke Authors

Cited Authors

  • Khouri, MG; Maurer, MS; El-Khoury Rumbarger, L

Published Date

  • May 2005

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 118 - 125

PubMed ID

  • 15886537

International Standard Serial Number (ISSN)

  • 1076-7460

Digital Object Identifier (DOI)

  • 10.1111/j.1076-7460.2005.03845.x


  • eng

Conference Location

  • United States