Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.

Journal Article (Journal Article)

Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) domains are critical components of signal transduction pathways that serve to relay signals originating from the cell surface to the interior of the cell. Src-like adapter protein (SLAP) is a recently described adapter protein that binds activated the Eck receptor protein-tyrosine kinase. Although SLAP bears a striking homology to the SH3 and SH2 domains of the Src family of nonreceptor tyrosine kinases, it does not contain a tyrosine kinase catalytic domain. In this report, the Slap gene was mapped by linkage analysis to mouse chromosome 15, while its putative human homolog (SLA) was identified and mapped to human 8q22.3-qter using a panel of somatic cell hybrids.

Full Text

Duke Authors

Cited Authors

  • Angrist, M; Wells, DE; Chakravarti, A; Pandey, A

Published Date

  • December 1995

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 623 - 625

PubMed ID

  • 8825655

Electronic International Standard Serial Number (EISSN)

  • 1089-8646

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1995.1289


  • eng