Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.
Journal Article (Journal Article)
A significant increase in tumor regression was induced in N-nitroso-N-methylurea-induced mammary tumors in rats treated with the combination of melatonin and 9-cis-retinoic acid (9cRA). Treatment groups included: control (ethanolic saline), 9cRA (30 mg/kg chow/day), melatonin 500 microg/day, melatonin 1000 microg/day, melatonin 500 microg/day+9cRA and melatonin 1000 microg/day+9cRA. Rats treated with the lower dose of melatonin 500 microg+9cRA show the greatest degree of tumor regression (78%), with 54% undergoing complete regression and a significant increase in apoptotic cells observed by TUNEL Assay. Furthermore, tumor multiplicity and burden were significantly decreased by the combination of melatonin and 9cRA.
Full Text
Duke Authors
Cited Authors
- Melancon, K; Cheng, Q; Kiefer, TL; Dai, J; Lai, L; Dong, C; Yuan, L; Collins, A; Thiyagarajah, A; Long, S; Hill, SM
Published Date
- September 8, 2005
Published In
Volume / Issue
- 227 / 1
Start / End Page
- 39 - 48
PubMed ID
- 16051031
International Standard Serial Number (ISSN)
- 0304-3835
Digital Object Identifier (DOI)
- 10.1016/j.canlet.2005.01.005
Language
- eng
Conference Location
- Ireland