Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.

Journal Article (Journal Article)

A significant increase in tumor regression was induced in N-nitroso-N-methylurea-induced mammary tumors in rats treated with the combination of melatonin and 9-cis-retinoic acid (9cRA). Treatment groups included: control (ethanolic saline), 9cRA (30 mg/kg chow/day), melatonin 500 microg/day, melatonin 1000 microg/day, melatonin 500 microg/day+9cRA and melatonin 1000 microg/day+9cRA. Rats treated with the lower dose of melatonin 500 microg+9cRA show the greatest degree of tumor regression (78%), with 54% undergoing complete regression and a significant increase in apoptotic cells observed by TUNEL Assay. Furthermore, tumor multiplicity and burden were significantly decreased by the combination of melatonin and 9cRA.

Full Text

Duke Authors

Cited Authors

  • Melancon, K; Cheng, Q; Kiefer, TL; Dai, J; Lai, L; Dong, C; Yuan, L; Collins, A; Thiyagarajah, A; Long, S; Hill, SM

Published Date

  • September 8, 2005

Published In

Volume / Issue

  • 227 / 1

Start / End Page

  • 39 - 48

PubMed ID

  • 16051031

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2005.01.005


  • eng

Conference Location

  • Ireland