Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice.
Publication
, Journal Article
Collins, A; Yuan, L; Kiefer, TL; Cheng, Q; Lai, L; Hill, SM
Published in: Cancer Lett
January 10, 2003
Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells significantly enhances the response of these cells to the growth-inhibitory actions of melatonin. Athymic nude mice implanted with MT1-overexpressing MCF-7 cells developed significantly fewer palpable tumors (60% reduction) compared to mice receiving vector-transfected MCF-7 cells (vt-MCF-7). In response to exogenous melatonin, tumor incidence in the mice receiving the MT1-overexpressing MCF-7 cells was decreased by 80% compared to mice receiving vt-MCF-7 cells. Interestingly, daily melatonin administration did not decrease tumor incidence in mice receiving vt-MCF-7 cells, but rather stimulated overall tumor formation.
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Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
January 10, 2003
Volume
189
Issue
1
Start / End Page
49 / 57
Location
Ireland
Related Subject Headings
- Tumor Cells, Cultured
- Transplantation, Heterologous
- Transfection
- Receptors, Melatonin
- Receptors, Cytoplasmic and Nuclear
- Receptors, Cell Surface
- Oncology & Carcinogenesis
- Neoplasm Transplantation
- Mice, Nude
- Mice
Citation
APA
Chicago
ICMJE
MLA
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Collins, A., Yuan, L., Kiefer, T. L., Cheng, Q., Lai, L., & Hill, S. M. (2003). Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. Cancer Lett, 189(1), 49–57. https://doi.org/10.1016/s0304-3835(02)00502-5
Collins, A., L. Yuan, T. L. Kiefer, Q. Cheng, L. Lai, and S. M. Hill. “Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice.” Cancer Lett 189, no. 1 (January 10, 2003): 49–57. https://doi.org/10.1016/s0304-3835(02)00502-5.
Collins A, Yuan L, Kiefer TL, Cheng Q, Lai L, Hill SM. Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. Cancer Lett. 2003 Jan 10;189(1):49–57.
Collins, A., et al. “Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice.” Cancer Lett, vol. 189, no. 1, Jan. 2003, pp. 49–57. Pubmed, doi:10.1016/s0304-3835(02)00502-5.
Collins A, Yuan L, Kiefer TL, Cheng Q, Lai L, Hill SM. Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. Cancer Lett. 2003 Jan 10;189(1):49–57.
Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
January 10, 2003
Volume
189
Issue
1
Start / End Page
49 / 57
Location
Ireland
Related Subject Headings
- Tumor Cells, Cultured
- Transplantation, Heterologous
- Transfection
- Receptors, Melatonin
- Receptors, Cytoplasmic and Nuclear
- Receptors, Cell Surface
- Oncology & Carcinogenesis
- Neoplasm Transplantation
- Mice, Nude
- Mice