Involvement of the mt1 melatonin receptor in human breast cancer.

Published

Journal Article

Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mt1 receptor, but not the MT2 receptor, is expressed in human breast tumor cell lines, and melatonin-induced growth suppression can be mimicked by the mt1 and MT2 agonist, AMMTC, and blocked by the antagonist, CBPT. RORalpha receptors are also expressed in MCF-7 breast cancer cells and the putative RORalpha agonist CPG-52608 inhibits MCF-7 cell growth but with a very different dose-response than melatonin. Finally, melatonin and AMMTC, but not CPG-52608, can repress RORalpha transcriptional activity in MCF-7 cells.

Full Text

Duke Authors

Cited Authors

  • Ram, PT; Dai, J; Yuan, L; Dong, C; Kiefer, TL; Lai, L; Hill, SM

Published Date

  • May 28, 2002

Published In

Volume / Issue

  • 179 / 2

Start / End Page

  • 141 - 150

PubMed ID

  • 11888668

Pubmed Central ID

  • 11888668

International Standard Serial Number (ISSN)

  • 0304-3835

Language

  • eng

Conference Location

  • Ireland