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Involvement of the mt1 melatonin receptor in human breast cancer.

Publication ,  Journal Article
Ram, PT; Dai, J; Yuan, L; Dong, C; Kiefer, TL; Lai, L; Hill, SM
Published in: Cancer Lett
May 28, 2002

Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mt1 receptor, but not the MT2 receptor, is expressed in human breast tumor cell lines, and melatonin-induced growth suppression can be mimicked by the mt1 and MT2 agonist, AMMTC, and blocked by the antagonist, CBPT. RORalpha receptors are also expressed in MCF-7 breast cancer cells and the putative RORalpha agonist CPG-52608 inhibits MCF-7 cell growth but with a very different dose-response than melatonin. Finally, melatonin and AMMTC, but not CPG-52608, can repress RORalpha transcriptional activity in MCF-7 cells.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

May 28, 2002

Volume

179

Issue

2

Start / End Page

141 / 150

Location

Ireland

Related Subject Headings

  • Tumor Cells, Cultured
  • Trans-Activators
  • Thiosemicarbazones
  • Thiazoles
  • Reverse Transcriptase Polymerase Chain Reaction
  • Recombinant Fusion Proteins
  • Receptors, Melatonin
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Cell Surface
  • RNA, Messenger
 

Citation

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Ram, P. T., Dai, J., Yuan, L., Dong, C., Kiefer, T. L., Lai, L., & Hill, S. M. (2002). Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett, 179(2), 141–150. https://doi.org/10.1016/s0304-3835(01)00873-4
Ram, P. T., J. Dai, L. Yuan, C. Dong, T. L. Kiefer, L. Lai, and S. M. Hill. “Involvement of the mt1 melatonin receptor in human breast cancer.Cancer Lett 179, no. 2 (May 28, 2002): 141–50. https://doi.org/10.1016/s0304-3835(01)00873-4.
Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, et al. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett. 2002 May 28;179(2):141–50.
Ram, P. T., et al. “Involvement of the mt1 melatonin receptor in human breast cancer.Cancer Lett, vol. 179, no. 2, May 2002, pp. 141–50. Pubmed, doi:10.1016/s0304-3835(01)00873-4.
Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, Hill SM. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett. 2002 May 28;179(2):141–150.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

May 28, 2002

Volume

179

Issue

2

Start / End Page

141 / 150

Location

Ireland

Related Subject Headings

  • Tumor Cells, Cultured
  • Trans-Activators
  • Thiosemicarbazones
  • Thiazoles
  • Reverse Transcriptase Polymerase Chain Reaction
  • Recombinant Fusion Proteins
  • Receptors, Melatonin
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Cell Surface
  • RNA, Messenger