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Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.

Publication ,  Journal Article
Teplitzky, SR; Kiefer, TL; Cheng, Q; Dwivedi, PD; Moroz, K; Myers, L; Anderson, MB; Collins, A; Dai, J; Yuan, L; Spriggs, LL; Blask, DE; Hill, SM
Published in: Cancer Lett
July 26, 2001

In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response did not reach statistical significance. Tumor incidence was significantly inhibited to 20% in the animals that received melatonin and 9cRA on alternating days. Latency to tumor onset was prolonged in animals receiving either of the combination treatments compared with controls, and tumor multiplicity was also significantly decreased.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

July 26, 2001

Volume

168

Issue

2

Start / End Page

155 / 163

Location

Ireland

Related Subject Headings

  • Uterus
  • Tretinoin
  • Retinoic Acid Receptor alpha
  • Receptors, Retinoic Acid
  • Receptors, Estrogen
  • Rats, Sprague-Dawley
  • Rats
  • Organ Size
  • Oncology & Carcinogenesis
  • Methylnitrosourea
 

Citation

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Teplitzky, S. R., Kiefer, T. L., Cheng, Q., Dwivedi, P. D., Moroz, K., Myers, L., … Hill, S. M. (2001). Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett, 168(2), 155–163. https://doi.org/10.1016/s0304-3835(01)00548-1
Teplitzky, S. R., T. L. Kiefer, Q. Cheng, P. D. Dwivedi, K. Moroz, L. Myers, M. B. Anderson, et al. “Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.Cancer Lett 168, no. 2 (July 26, 2001): 155–63. https://doi.org/10.1016/s0304-3835(01)00548-1.
Teplitzky SR, Kiefer TL, Cheng Q, Dwivedi PD, Moroz K, Myers L, et al. Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett. 2001 Jul 26;168(2):155–63.
Teplitzky, S. R., et al. “Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid.Cancer Lett, vol. 168, no. 2, July 2001, pp. 155–63. Pubmed, doi:10.1016/s0304-3835(01)00548-1.
Teplitzky SR, Kiefer TL, Cheng Q, Dwivedi PD, Moroz K, Myers L, Anderson MB, Collins A, Dai J, Yuan L, Spriggs LL, Blask DE, Hill SM. Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett. 2001 Jul 26;168(2):155–163.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

July 26, 2001

Volume

168

Issue

2

Start / End Page

155 / 163

Location

Ireland

Related Subject Headings

  • Uterus
  • Tretinoin
  • Retinoic Acid Receptor alpha
  • Receptors, Retinoic Acid
  • Receptors, Estrogen
  • Rats, Sprague-Dawley
  • Rats
  • Organ Size
  • Oncology & Carcinogenesis
  • Methylnitrosourea