Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.

Published

Journal Article

Prostaglandin E(2) (PGE(2)) plays an important role in the normal physiology of many organ systems. Increased levels of this lipid mediator are associated with many disease states, and it potently regulates inflammatory responses. Three enzymes capable of in vitro synthesis of PGE(2) from the cyclooxygenase metabolite PGH(2) have been described. Here, we examine the contribution of one of these enzymes to PGE(2) production, mPges-2, which encodes microsomal prostaglandin synthase-2 (mPGES-2), by generating mice homozygous for the null allele of this gene. Loss of mPges-2 expression did not result in a measurable decrease in PGE(2) levels in any tissue or cell type examined from healthy mice. Taken together, analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase.

Full Text

Cited Authors

  • Jania, LA; Chandrasekharan, S; Backlund, MG; Foley, NA; Snouwaert, J; Wang, I-M; Clark, P; Audoly, LP; Koller, BH

Published Date

  • April 2009

Published In

Volume / Issue

  • 88 / 3-4

Start / End Page

  • 73 - 81

PubMed ID

  • 19010439

Pubmed Central ID

  • 19010439

International Standard Serial Number (ISSN)

  • 1098-8823

Digital Object Identifier (DOI)

  • 10.1016/j.prostaglandins.2008.10.003

Language

  • eng