Effect of anger provocation on endothelium-dependent and -independent vasodilation.

Journal Article (Journal Article)

Anger is an independent predictor of coronary heart disease events, although the mechanisms for this relation are unclear. The effects of an anger-provoking interview compared with a neutral interview on endothelium-dependent and -independent vasodilation assessed by brachial artery ultrasound were examined in 14 healthy subjects without coronary heart disease risk factors. The anger provocation condition, but not the neutral condition, caused a significant impairment in endothelium-dependent vasodilation at 90 minutes compared with baseline (p = 0.004) and 30 minutes (p = 0.013). Similarly, endothelium-independent vasodilation was significantly impaired at 90 minutes after the angry interview compared with baseline (p = 0.003) and 30 minutes (p = 0.001). The decreases in endothelium-dependent and -independent vasodilation were greater after the anger-provoking interview than after the neutral interview, especially between 30 and 90 minutes. In conclusion, preliminary results suggest that an episode of anger is associated with a dysregulation in endothelium-dependent and -independent pathways, suggesting that these mechanisms might contribute to the link between anger and coronary heart disease events.

Full Text

Duke Authors

Cited Authors

  • Shimbo, D; Chaplin, W; Akinola, O; Harris, A; Abraham, D; Homma, S; Gerin, W

Published Date

  • March 15, 2007

Published In

Volume / Issue

  • 99 / 6

Start / End Page

  • 860 - 863

PubMed ID

  • 17350383

Pubmed Central ID

  • PMC1865576

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2006.10.051


  • eng

Conference Location

  • United States