Stress, coping, and circadian disruption among women awaiting breast cancer surgery.

Published

Journal Article

BACKGROUND: Psychological distress and coping related to a breast cancer diagnosis can profoundly affect psychological adjustment, possibly resulting in the disruption of circadian rest/activity and cortisol rhythms, which are prognostic for early mortality in metastatic colorectal and breast cancers, respectively. PURPOSE: This study aims to explore the relationships of cancer-specific distress and avoidant coping with rest/activity and cortisol rhythm disruption in the period between diagnosis and breast cancer surgery. METHODS: Fifty-seven presurgical breast cancer patients provided daily self-reports of cancer-specific distress and avoidant coping as well as actigraphic and salivary cortisol data. RESULTS: Distress and avoidant coping were related to rest/activity rhythm disruption (daytime sedentariness, inconsistent rhythms). Patients with disrupted rest/activity cycles had flattened diurnal cortisol rhythms. CONCLUSIONS: Maladaptive psychological responses to breast cancer diagnosis were associated with disruption of circadian rest/activity rhythms. Given that circadian cycles regulate tumor growth, we need greater understanding of possible psychosocial effects in cancer-related circadian disruption.

Full Text

Duke Authors

Cited Authors

  • Dedert, E; Lush, E; Chagpar, A; Dhabhar, FS; Segerstrom, SC; Spiegel, D; Dayyat, E; Daup, M; McMasters, K; Sephton, SE

Published Date

  • August 2012

Published In

Volume / Issue

  • 44 / 1

Start / End Page

  • 10 - 20

PubMed ID

  • 22450856

Pubmed Central ID

  • 22450856

Electronic International Standard Serial Number (EISSN)

  • 1532-4796

Digital Object Identifier (DOI)

  • 10.1007/s12160-012-9352-y

Language

  • eng

Conference Location

  • England