Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer.

Journal Article (Journal Article)

PURPOSE: This study evaluated the strategy of performing neck dissection (ND) without primary tumor resection prior to definitive chemoradiotherapy (CRT) for N2+ oropharynx cancer. METHODS: We analyzed records of 25 patients who underwent ND before concurrent CRT with weekly low-dose concurrent paclitaxel and a platinum compound. The extent of ND was highly customized (1 to 39 nodes) and median radiotherapy dose was 70 Gy. RESULTS: Median follow-up was 36 months. Two-year and 3-year actuarial locoregional control rates were 95% and 88%. No patient had regional neck nodal failure. Two-year rate of freedom from distant metastases was 91%. The 2- and 3-year event-free survival rates were 88% and 75%. Fifteen percent had Grade 3+ late toxicity; none had permanent gastrostomy tube dependence. CONCLUSIONS: Neck dissection without primary tumor resection before definitive chemoradiotherapy for oropharynx cancer is a safe and effective management program and warrants further exploration.

Full Text

Duke Authors

Cited Authors

  • Cupino, A; Axelrod, R; Anne, PR; Sidhu, K; Lavarino, J; Kung, B; Rosen, M; Keane, W; Machtay, M

Published Date

  • September 2007

Published In

Volume / Issue

  • 137 / 3

Start / End Page

  • 416 - 421

PubMed ID

  • 17765768

International Standard Serial Number (ISSN)

  • 0194-5998

Digital Object Identifier (DOI)

  • 10.1016/j.otohns.2007.03.021


  • eng

Conference Location

  • England