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Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer.

Publication ,  Journal Article
Cupino, A; Axelrod, R; Anne, PR; Sidhu, K; Lavarino, J; Kung, B; Rosen, M; Keane, W; Machtay, M
Published in: Otolaryngol Head Neck Surg
September 2007

PURPOSE: This study evaluated the strategy of performing neck dissection (ND) without primary tumor resection prior to definitive chemoradiotherapy (CRT) for N2+ oropharynx cancer. METHODS: We analyzed records of 25 patients who underwent ND before concurrent CRT with weekly low-dose concurrent paclitaxel and a platinum compound. The extent of ND was highly customized (1 to 39 nodes) and median radiotherapy dose was 70 Gy. RESULTS: Median follow-up was 36 months. Two-year and 3-year actuarial locoregional control rates were 95% and 88%. No patient had regional neck nodal failure. Two-year rate of freedom from distant metastases was 91%. The 2- and 3-year event-free survival rates were 88% and 75%. Fifteen percent had Grade 3+ late toxicity; none had permanent gastrostomy tube dependence. CONCLUSIONS: Neck dissection without primary tumor resection before definitive chemoradiotherapy for oropharynx cancer is a safe and effective management program and warrants further exploration.

Duke Scholars

Published In

Otolaryngol Head Neck Surg

DOI

ISSN

0194-5998

Publication Date

September 2007

Volume

137

Issue

3

Start / End Page

416 / 421

Location

England

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Radiotherapy Dosage
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Neoadjuvant Therapy
  • Neck Dissection
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Cupino, A., Axelrod, R., Anne, P. R., Sidhu, K., Lavarino, J., Kung, B., … Machtay, M. (2007). Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer. Otolaryngol Head Neck Surg, 137(3), 416–421. https://doi.org/10.1016/j.otohns.2007.03.021
Cupino, Andrew, Rita Axelrod, P Rani Anne, Kulbir Sidhu, Jorosali Lavarino, Brian Kung, Marc Rosen, William Keane, and Mitchell Machtay. “Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer.Otolaryngol Head Neck Surg 137, no. 3 (September 2007): 416–21. https://doi.org/10.1016/j.otohns.2007.03.021.
Cupino A, Axelrod R, Anne PR, Sidhu K, Lavarino J, Kung B, et al. Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer. Otolaryngol Head Neck Surg. 2007 Sep;137(3):416–21.
Cupino, Andrew, et al. “Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer.Otolaryngol Head Neck Surg, vol. 137, no. 3, Sept. 2007, pp. 416–21. Pubmed, doi:10.1016/j.otohns.2007.03.021.
Cupino A, Axelrod R, Anne PR, Sidhu K, Lavarino J, Kung B, Rosen M, Keane W, Machtay M. Neck dissection followed by chemoradiotherapy for stage IV (N+) oropharynx cancer. Otolaryngol Head Neck Surg. 2007 Sep;137(3):416–421.
Journal cover image

Published In

Otolaryngol Head Neck Surg

DOI

ISSN

0194-5998

Publication Date

September 2007

Volume

137

Issue

3

Start / End Page

416 / 421

Location

England

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Radiotherapy Dosage
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Neoadjuvant Therapy
  • Neck Dissection
  • Middle Aged
  • Male
  • Humans