Glutathione-s-transferase-pi expression in early breast cancer: association with outcome and response to chemotherapy.

Journal Article (Journal Article)

Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 %. There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p =.055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies.

Full Text

Duke Authors

Cited Authors

  • Arun, BK; Granville, LA; Yin, G; Middleton, LP; Dawood, S; Kau, S-W; Kamal, A; Hsu, L; Hortobagyi, GN; Sahin, AA

Published Date

  • June 2010

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 554 - 559

PubMed ID

  • 20210524

Pubmed Central ID

  • 20210524

Electronic International Standard Serial Number (EISSN)

  • 1532-4192

Digital Object Identifier (DOI)

  • 10.3109/07357900903286925


  • eng

Conference Location

  • England