Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.

Published

Journal Article

PURPOSE: To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma. EXPERIMENTAL DESIGN: Twenty-three mitochondrial mutations were identified in 12 tumors using a high-throughput mitochondrial sequencing array. Areas of adjacent dysplastic and normal epithelium adjacent to tumors were sequenced using conventional methods for the presence of mutations that occurred in the corresponding tumor. RESULTS: Two of 23 (8.7%) tumor mitochondrial mutations (2 of 12 tumors) were present in both the areas of adjacent dysplasia and normal epithelium. Five of 23 (21.7%) tumor mitochondrial mutations (4 of 12 tumors) were present in areas of adjacent dysplasia. Eleven of 12 tumors contained nonsynonymous mutations that resulted in protein coding alterations. A significant difference (P < 0.01, chi(2)) was found in the incidence of mitochondrial mutation that occurred after development of cancer compared with adjacent areas dysplasia and normal epithelium. CONCLUSIONS: The majority of mitochondrial mutations occur during or after the transition of preneoplastic epithelium to cancer in head and neck squamous cell carcinoma, indicating that these are a late event in head and neck carcinogenesis.

Full Text

Duke Authors

Cited Authors

  • Mithani, SK; Taube, JM; Zhou, S; Smith, IM; Koch, WM; Westra, WH; Califano, JA

Published Date

  • August 1, 2007

Published In

Volume / Issue

  • 13 / 15 Pt 1

Start / End Page

  • 4331 - 4335

PubMed ID

  • 17671113

Pubmed Central ID

  • 17671113

International Standard Serial Number (ISSN)

  • 1078-0432

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-2613

Language

  • eng

Conference Location

  • United States