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Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.

Publication ,  Journal Article
Mithani, SK; Taube, JM; Zhou, S; Smith, IM; Koch, WM; Westra, WH; Califano, JA
Published in: Clin Cancer Res
August 1, 2007

PURPOSE: To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma. EXPERIMENTAL DESIGN: Twenty-three mitochondrial mutations were identified in 12 tumors using a high-throughput mitochondrial sequencing array. Areas of adjacent dysplastic and normal epithelium adjacent to tumors were sequenced using conventional methods for the presence of mutations that occurred in the corresponding tumor. RESULTS: Two of 23 (8.7%) tumor mitochondrial mutations (2 of 12 tumors) were present in both the areas of adjacent dysplasia and normal epithelium. Five of 23 (21.7%) tumor mitochondrial mutations (4 of 12 tumors) were present in areas of adjacent dysplasia. Eleven of 12 tumors contained nonsynonymous mutations that resulted in protein coding alterations. A significant difference (P < 0.01, chi(2)) was found in the incidence of mitochondrial mutation that occurred after development of cancer compared with adjacent areas dysplasia and normal epithelium. CONCLUSIONS: The majority of mitochondrial mutations occur during or after the transition of preneoplastic epithelium to cancer in head and neck squamous cell carcinoma, indicating that these are a late event in head and neck carcinogenesis.

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Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

August 1, 2007

Volume

13

Issue

15 Pt 1

Start / End Page

4331 / 4335

Location

United States

Related Subject Headings

  • Precancerous Conditions
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Head and Neck Neoplasms
  • Epithelium
  • Disease Progression
  • DNA, Neoplasm
  • DNA, Mitochondrial
 

Citation

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ICMJE
MLA
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Mithani, S. K., Taube, J. M., Zhou, S., Smith, I. M., Koch, W. M., Westra, W. H., & Califano, J. A. (2007). Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res, 13(15 Pt 1), 4331–4335. https://doi.org/10.1158/1078-0432.CCR-06-2613
Mithani, Suhail K., Janis M. Taube, Shaoyu Zhou, Ian M. Smith, Wayne M. Koch, William H. Westra, and Joseph A. Califano. “Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.Clin Cancer Res 13, no. 15 Pt 1 (August 1, 2007): 4331–35. https://doi.org/10.1158/1078-0432.CCR-06-2613.
Mithani SK, Taube JM, Zhou S, Smith IM, Koch WM, Westra WH, et al. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331–5.
Mithani, Suhail K., et al. “Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.Clin Cancer Res, vol. 13, no. 15 Pt 1, Aug. 2007, pp. 4331–35. Pubmed, doi:10.1158/1078-0432.CCR-06-2613.
Mithani SK, Taube JM, Zhou S, Smith IM, Koch WM, Westra WH, Califano JA. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331–4335.

Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

August 1, 2007

Volume

13

Issue

15 Pt 1

Start / End Page

4331 / 4335

Location

United States

Related Subject Headings

  • Precancerous Conditions
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Head and Neck Neoplasms
  • Epithelium
  • Disease Progression
  • DNA, Neoplasm
  • DNA, Mitochondrial